The capstone project is the culmination of your master’s degree in translational biomedical informatics.
There are four aspects:
- Identifying a Lab
- Capstone Enrollment
Importantly, it is the vehicle to gain applied experience working within the research field, and ideally, it will aid in future career steps. There is flexibility in the format and deliverables, though a requirement of a capstone proposal is required to enroll in the course.
Tools for Identifying A Lab
There is no single best way to find a mentor, though it is recommended you start the process after becoming nominally proficient in basic bioinformatic and computing tools. For many students, this will be after there the first semester, though for some it may be sooner depending on their individual backgrounds. Your department will be able to give some advice on this topic, and the process can vary tremendously depending on your long term goals. While for most the mentor will be a USC faculty member, it is possible for the mentor to be an outside individual to be considered on a case-by-case if certain requirements can be made (such as the ability to share openly your work and work product).
The starting point for many emails to prospective labs. You will want to introduce yourself and have a short 1 to 2 paragraph query and introduction. You will want to mention some of your bioinformatics expertise or focus (R/R Shiny, Databases, Unix, Next-generation Sequencing).
There is no single way to identify a mentor, but utilizing colleagues, the internet and going to presentations are foundational. Clearly, starting by looking at the research and faculty within the Department of Translational Genomics is a great starting point. The research faculty are:
- Brooke Hjlem, Ph.D.
- Troy McEachron, Ph.D.
- David Craig, Ph.D.
- Bodour Salhia, Ph.D.
- Enrique Velazquez, Ph.D. MPH
- John Carpten, Ph.D.
- Zarko Manolojvich, Ph.D.
- Xiaowu Gai, Ph.D.
Keck School of Medicine
There are many faculty that work closely with the department and many faculty at USC who would make excellent mentors. Collaboration is at the heart of translational genomics. Departments indicating strong interest in Translational Biomedical Informatics Students:
- Department of Medicine
- Best initial contact is Matthew Salomon who leads informatics and is aware of different groups who have needs
- Department of Psychiatry
- Specific requests for those interested in databasing with genomics by Steven Siegel
- Stem Cell
- Various individuals, but Andrew McMahon has opportunities both in his lab and in others. RNA-seq, ChIP-seq, ATAC-seq, single-cell RNA-seq, single-cell-ATAC-seq, and Hi-C to identify the molecular mechanisms regulating maintenance and commitment of stem/progenitor populations in generation and repair of the mouse and human kidney
- Zilka Institute
- Berislav V. Zlokovic or individual labs may be the best approach
- Xiaowu Gai is a great contact who may be aware of many opportunities
Faculty who have expressed interest in bioinformatic students:
|Adam de Smith, PhD||Genetic Epidemiology||Assistant Professor|
|Andrew P. McMahon, PhD||Stem Cell||Professor|
|Caryn Lerman||Cancer Center||Professor|
|Dana Goldman, PhD||Public Policy||Professor|
|Daniel J. Weisenberger, PhD||Medicine||Associate Professor|
|Daniella Meeker, PhD||Preventive Medicine||Assistant Professor|
|Darcy Spicer, MD||Medicine||Associate Professor|
|Darryl Shibata, MD||Pathology||Professor|
|Jaclyn A. Biegel, PhD||Pediatrics||Professor|
|Jerry SH Lee, PhD||Medicine||Associate Professor|
|Jonathan David Buckley, MD, PhD||Preventive Medicine||Professor|
|Juan Pablo Lewinger, PhD||Preventive Medicine||Assistant Professor|
|Julie E. Lang, MD||Surgery||Associate Professor|
|Juliet Ann Emamaullee||Surgery||Assistant Professor|
|Justin Ichida, PhD||Stem Cell Biology||Assistant Professor|
|Kimberly Siegmund, PhD||Preventive Medicine||Professor|
|Linda Michelle Polfus, PhD||Genetic Epidemiology||Assistant Professor|
|Matthew Salomon||Medicine||Assistant Professor|
|Michael Anthony Bonaguidi, PhD||Stem Cell Biology||Assistant Professor|
|Michael R. Lieber, MD, PhD||Pathology||Professor|
|Paul Marjoram, PhD||Preventive Medicine||Professor|
|Peter Kuhn, PhD||Broad CIRM Center||Professor|
|Pinchas Cohen, MD||Gerontology||Professor|
|Rangasamy Ramanathan, MD||Pediatrics||Professor|
|Ricky Bluthenthal, PhD||Institute for Health||Associate Professor|
|Sarah Hamm-Alvarez, PhD||Ophthalmology||Associate Professor|
|Shahab Asgharzadeh, MD||Pediatrics||Associate Professor|
|Steve Kay, PhD||Zilkha Neurogenetic||Professor|
|Steven Siegel, MD, PhD||Psychiatry||Chair|
|Timothy J Triche, MD, PhD||Pediatrics||Professor|
|W. Martin Kast, PhD||Molecular Microbiology||Professor|
|Wendy Cozen, DO, MPH||Preventive Medicine||Professor|
USC Health Science Profiles - Learn about Keck Faculty
An automated tool that has information about each faculty. This tool is great for doing searches within areas!
NIH Reporter: Identifies labs with funding
Often the labs with the greatest opportunities have NIH grants. This database is great - remember to limit to USC to see all the different labs with substantial NIH funding.
After working some time in your lab or research environment, you'll want to start defining what will be your Capstone deliverable. Remember, in the beginning, you want to learn and develop from the lab. The right capstone deliverable will typically be pretty clear after a few months, but it should be something that really showcases what you are learning and the experience you are gaining.
You will work with the course director on the specifics of your capstone, and there is some variability in these.
Example deliverables include:
- Publications (e.g. Journal)
- Scientific Poster at a Major Conference
- Technical White Paper, e.g. Biorxv
- GitHub Repositories
There is not a requirement for a traditional academic style presentation, and various forms can be used including video, websites, the publication (PDF), and other media. Ideally, the presentation can be done in a way that retains your ability to show people the work in the future.